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(b) Single small case series in knee pain A peer-reviewed article (Lee et al., Alternative Therapies in Health & Medicine , ~2021) describes: 12 patients with chronic knee pain Treated with intra-articular BPC-157, often combined with TB-500 7 of 12 reported symptom improvement lasting several months This study has major limitations: No control group No blinding No standardized outcomes (no KOOS, WOMAC, or imaging) Very small sample size Mixed interventions Conclusion: This study cannot demonstrate true benefit

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In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

These incentives are particularly valuable for peptide drugs targeting rare conditions where traditional market forces might not support development