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The incretin hormone glucagonlike peptide 1 increases mitral cell excitability by decreasing conductance of a voltagedependent potassium channel

The lipolytic stimulus is switched off by removal of the stimulating hormone

1,35 Most importantly, four different long-acting GLP-1RAs (liraglutide, albiglutide, semaglutide and dulaglutide) have been found to the reduce risk of future major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal myocardial infarction and stroke) in patients with T2D, with the other long-acting GLP-1RAs, exenatide once-weekly (exeOW) showing a trend towards reduction in MACE combined with a nominally significant reduction in overall mortality

Too much glucagon activation could cause excessive blood sugar elevation

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