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Pathway VIII arises mainly owing to oncogenes that activate the G--q pathway, with the most common genetic alteration being activating mutations in GNAQ or in GNA11

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Secondary endpoints included time from randomization to the first occurrence of an expanded composite outcome consisting of the primary outcome plus unstable angina resulting in hospitalization or heart failure resulting in hospitalization or a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke

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