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For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)

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Abbreviations AHU: Asymptomatic hyperuricemia MS: Mass spectrometry DBS: Dried blood spot Orn: Ornithine His: Histidine Pip: Piperamide C0: Free carnitine C2: Acetylcarnitine C3: Propionylcarnitine Gly: Glycine C4: Butyrylcarnitine C16: Palmitoylcarnitine MSU: Monosodium urate SUA: Serum uric acid GC: Gas chromatography LC: Liquid chromatography AGA: Acute gout arthritis QC: Quality control PCA: Principal component analysis PLS-DA: Partial least squares discriminant analysis VIP: Variable importance in projection FDR: False discovery rate ROC: Receiver-operating characteristic AUC: Area under the ROC curve BMI: Body-Mass Index LDL: Low density lipoprotein SBP: Systolic blood pressure DBP: Diastolic blood pressure AST: Aspartate aminotransferase ALT: Alanine aminotransferase HDL: High density lipoprotein eGFR: Estimated glomerular filtration rate Thr: Threonine Trp: Tryptophan Pro: Proline Tyr: Tyrosine C5: Isovalerylcarnitine Arg: Arginine Cit: Citrulline Ala: Alanine Phe: Phenylalanine Asn: Asparagine Glu: Glutamic Val: Glutamic Leu: Leucine Ser: Serine MRP4: Multidrug resistance protein 4 BCRP: Breast cancer resistance protein BCAA: Branched chain amino acid Cys: Cysteine OTCD: Ornithine transcarbamylase deficiency CACT: Carnitine-acylcarnitine translocase References Towiwat P, Chhana A, Dalbeth N

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