glp-1 and serotonin Anti-Obesity Rx Alcohol and Substance Use Disorders Glucagon-like peptide-1 and its analogues

Free practical resources I created two companion resources to help turn this discussion into practical action

Providers pivoted

The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity

The more useful question is whether the professional formulation is better matched to the individuals reason for taking it

These include tobacco smoking (which can reduce melatonin levels), excessive caffeine consumption (especially in the evenings, which can disrupt natural sleep patterns), and alcohol intake (which can reduce melatonins sleep-inducing effects)