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Molecular Design and Rationale 2.1

It has been speculated that extracellular GS may play a role in the production of poly-L-glutamine-glutamate [25], a polymer found only in pathogenic mycobacterial cell walls, and/or that extracellular GS activity may modulate phagosome pH and thereby prevent phagasome-lysosome fusion [23, 24]

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