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It remains active in the body for extended periods, aiding appetite control and blood sugar regulation

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Moreover, in patients with T2DM, islet amyloid polypeptide (IAPP or amylin), a peptide hormone and one of the main secretory products of pancreatic -cells, tends to deposit in the islets of Langerhans, form insoluble fibrils and impair secretory functions of -cells (93)

It has been speculated that incretin analogs may engage additional mechanisms (i.e., anti-inflammatory, vasculo-protective etc.) that could account for their observed clinical efficacy

This introductory dose allows the body to adjust to GLP-1 receptor activation with minimal side effects