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Patients with a sulfa allergy should avoid medications classified as sulfonamides
However, the substantial weight loss they facilitate does result in some loss of lean body mass, as occurs with any significant weight reduction
This may be inconvenient for individuals who want immediate weight loss, but you may begin feeling its effects as soon as you take your first dose
In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)
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