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In addition, the LIRA-FLAME trial (NCT03449654) is examining the effects of liraglutide vs

In parallel, LPS and inflammation perturb hepatic clock gene expression and time-of-day responses (for example altering Per and, in specific contexts, BMAL1 expression), which further deranges metabolic rhythmicity and amplifies vulnerability to steatotic progression

This could theoretically alter the peak plasma concentration (Cmax) and time to peak concentration (Tmax) of co-administered oral drugs

More directly, tumors shed bioactive lipids to engage specific extracellular receptors on immune cells [135, 148,149,150,151]