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Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

Insulin resistance alters nutrient partitioning, potentially directing fewer resources toward muscle preservation

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The two coronavirus sites with exact P4-P1 matches to GCLC are those at either end of nsp5, i.e., M pro itself, which have the highest catalytic efficiency for cleavage of any of the viral M pro targets (100 and 41%)