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While clinical trials show significant average weight loss with GLP-1 medications, results are not guaranteed and some patients experience more modest outcomes

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Patients who have taken tirzepatide and other GIP/GLP-1 RA drugs, including semaglutide, have developed life-altering and fatal health problems

Proponents of GLP-1 agonists highlight the drugs effectiveness in curbing appetite and promoting weight loss, while opponents argue the drugs come with serious side effects and cost too much to make a dent in the obesity crisis

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