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As detailed in the current review, semaglutide appears not to increase the risk of pancreatitis (yet nevertheless it has been added to the SmPC to align with health authorities expectations on class labeling), but it is associated with more events of cholelithiasis

That shift helps explain the extraordinary enthusiasm surrounding GLP-1 medications

Its preservative is why reconstituted vials tolerate repeated sampling over weeks rather than days

However, Alawad noted a slight decreasing trend toward lower right heart failure in the GLP-1 group

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