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Two additional uricosuric drugs, sulfinpyrazone and benzbromarone are no longer used in the US due to toxicities

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This process is a major contributor to the visible signs of aging and the decline of cellular function

This study was initiated in a reverse translational approach, from GSH-deficient mouse model to EP patients, following the observations of specific structural and functional alterations in the hippocampus 39 and fornix 36 in Gclm -KO mice