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muscle) Lab tests (thyroid, insulin resistance, lipids, vitamin levels, inflammation markers) Screening for hormonal issues (e.g., PCOS, menopause-related weight gain) Why it matters: Weight gain is often influenced by hormones, gut health, stress, medications, or metabolic dysfunctionnot just overeating

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3.3.4 Leptin and ghrelin Leptin is a recognized hormone that enhances satiety and energy expenditure, primarily produced by adipocytes [52]

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These ECM components undergo modifications by binding with soluble factors, including growth factors and other ECM-associated proteins (Hynes, 2009)