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Acknowledgements This study was supported by the National Natural Science Foundation of China (grants 32271048, 32571336, 32070999 to Y.Z., grant 82471311 to W.H., and grant 823B2022 to X.Y.W), the Leading Medicine and Advanced Technologies of IHM (grant 2025IHM01100 to Y.Z.), and Anhui Provincial Natural Science Foundation (grant 2008085J16 to Y.Z.)

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