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That is a clinically meaningful difference, and it has influenced how doctors view the two options for their patients

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type

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While SGLT-2is (e.g., empagliflozin, canagliflozin) and DDP-4is (e.g., sitagliptin) are exclusively available as orally administered medications, both oral and subcutaneous formulations of the GPL-1RA semaglutide are available