This depends on the specific formulation, preservatives used, and packaging integrity
Contact your GP or prescribing clinician if: Headaches are frequent, severe, or worsening over time Headaches significantly interfere with daily activities or quality of life Over-the-counter pain relief is ineffective or you find yourself taking painkillers regularly You have a history of migraines that have become more frequent or severe since starting Wegovy Headaches are accompanied by persistent nausea, vomiting, or other concerning symptoms You are uncertain whether to continue your Wegovy treatment Your healthcare provider can assess whether the headaches are related to Wegovy, investigate other potential causes, and discuss appropriate management strategies
The American Society for Anesthesiology updated their pre-operative fasting guidelines in 2023 and recommended that GLP-1 receptor agonists should be held for 1 week, despite lacking data
It notes that semaglutide was present in the milk of lactating rats, but adds that due to species-specific differences in lactation physiology, the clinical relevance of these data is not clear
Individual variation in drug response is significantbiological differences in GLP-1 receptor expression and function may contribute to why some patients naturally respond more robustly than others, though this is not routinely assessed in clinical practice