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For injectable routes, beyond localized reactions like pain or swelling at the injection site, observing for systemic effects becomes paramount

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PMCID: PMC9268622

Patients should not adjust doses of either medication independently

Hepatic and Metabolic Benefits A MAFLD/MASLD (metabolic dysfunction-associated steatotic liver disease) sub-study of the Phase 2 obesity trial reported that over 85% of participants on the highest retatrutide doses achieved more than 30% reduction in liver fat content measured by MRI, with many reaching complete resolution of steatosis