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For example, Angong Niuhuang Wan inhibits the accumulation of ROS and Fe 2+ and improves mitochondrial dysfunction and BBB structural integrity by activating the PPAR/AKT/GPX4 pathway, thereby enhancing neurological function in rats with ischemic stroke and reducing cerebral infarction volume

11 Overdevest GM, Moojen WA, Arts MP, Vleggeert-Lankamp CL, Jacobs WC, Peul WC

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Many dermatologists recommend this pairing because niacinamide keeps skin calm, while retinol gets to work reducing wrinkles

Understanding these distinctions helps supplement brands and formulators choose the right ingredient for specific applications