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Microbiome-directed probiotic interventions have shown promise in preclinical and clinical studies, ameliorating UC through multiple mechanisms, including anti-inflammatory activity, epithelial barrier restoration, and remodeling of the intestinal microbiota

Proteomics in the kidney marrow between young-adult and aged killifish showed age-dependent enhanced oxidative stress buffering, including increased glutathione metabolism and upregulation of peptides involved in detoxification processes, which may help clear accumulated metabolic byproducts, such as alcohols, hydroxy compounds and aldehydes