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Ultimately, the synergistic integration of pharmacological therapy and nutritional strategiesthrough adequate macronutrient and micronutrient intake, effective management of GI AEs, and preservation of MMhas the potential to significantly enhance clinical outcomes [67, 95]

8-10 The Role of GPX4 Normally, highly reactive lipid peroxides are reduced to non-reactive lipid alcohols by the activity of the essential enzyme glutathione hydroperoxidase 4 (GPX4)

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