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Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury

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doi:10.1136/bmj.r1512 Chen, J., Siliceo, S.L., Ni, Y., Nielsen, H.B., Xu, A., & Panagiotou, G

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B12 plays a starring role in several processes like making red blood cells, converting food into energy, forming new DNA, and producing nerves

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Pharmacological inhibition of the MVA pathway impairs Sec-tRNA biogenesis, leading to GPX4 inactivation, diminished cellular antioxidant defenses, lipid peroxide accumulation, and ultimately ferroptosis induction ( Recent studies demonstrate that the bisphosphonate alendronate synergistically enhances paclitaxel efficacy, suppresses tumor metastasis, and modifies cytotoxic mechanisms in cancer therapy

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