Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]
independence in older age decreases Bone Health: Muscle loss accelerates bone density decline and increases fall risk Blood Sugar: Muscle is the primary site of glucose uptakeless muscle means worse blood sugar control Weight Maintenance: People who lose significant muscle regain weight more easily after stopping GLP-1s Quality of Life: Lower energy, reduced physical capability, decreased confidence The reality is that GLP-1 medications are incredibly effective at creating a caloric deficitsometimes too effective
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