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Selected Practice Recommendations for Contraceptive Use treats severe vomiting (and severe diarrhea) within 23 hours of taking the pill the same as a missed dose

doi:10.1530/JOE-10-0419 47

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Compared with placebo, the smallest percentage body-weight loss was observed in individuals with type 2 diabetes, with an estimated treatment difference of 6.2% after 68 weeks of treatment [35], whereas an additional body-weight loss of 10.312.5% after 68 weeks of treatment (without prior run-in with semaglutide) was observed in individuals without diabetes in trials aiming to directly compare semaglutide with placebo [26, 36, 38, 39] (Fig