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Next, we introduced multiple mutations in HGF, including point mutations (W321R, E336R, E361R, R373E, and Y376A), double mutation (W321R/Y376A), and triple mutation (W321R/E361R/Y376A), designed to weaken the interface III

Our combination therapy of (-)-Vestitol and Salviolone, identified via network medicine, targets multiple AD-related pathways, including Neuroactive ligand-receptor interaction and Calcium signaling pathway, potentially offering a more comprehensive, disease-modifying approach

It stimulates lipolysis, breaking down fat cells for energy, while inhibiting fat storage, making it an ideal fat-burning tool

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