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Research into triple-agonist peptides such as Retatrutide has expanded significantly since 2020, with published Phase 2 data (Jastreboff et al., 2023, New England Journal of Medicine) indicating substantial effects in human clinical trials on body weight and glycaemic parameters

Lifestyle support, cardiometabolic risk, reproductive goals, and medication access all shape the plan

Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation

Mol Neurobiol 2019;56:1188-95

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