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Clinical studies have shown that the most significant results are often observed after 12 months of consistent use, with ongoing benefits as long as therapy continues
Read more Stopping GLP-1 medications can trigger weight regain and metabolic changes
This is the earliest and most immediately perceptible effect
E-values were calculated for pre-specified outcomes to assess the potential influence of unmeasured confounders 52
In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight
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