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According to research principles: Clinical trial results represent average outcomes under ideal conditions with: Highly selected participants (extensive exclusion criteria) Monthly professional monitoring and support Free medication (eliminates cost barriers) Structured lifestyle interventions High adherence rates Real-world results may differ due to: Variable medication adherence Different lifestyle modification levels Varying dose levels reached Cost/access barriers affecting consistency Less frequent monitoring Individual metabolic differences Some individuals exceed clinical trial results

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Diabetes 2016, 65: 172187

In people with T2D, this examination is conducted at diagnosis of T2D, whereas for T1D, it should be performed after 5 years and then in both groups annually [22]

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