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Claudin-5 contributes to the reduced paracellular ion movement and helps narrow the paracellular cleft [11, 14, 15]

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Moreover, presenting that the most threatening period may be the seizures-period, and the regular duration estimated to be 5 hours, and that at the time point of 3 hours following paracetamol the rats would exhibit generalized convulsions for the next two subsequent hours, it is interesting that after BPC 157 application the generalized convulsions disappeared within the next 25 minutes and the rats regained posture, still sleepy, with a tottering walk for the next 50 minutes