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The trade-offs among clinical effectiveness, tolerability, and cost for GLP-1RA use have highlighted the importance of a cost-effectiveness analysis (CEA) of GLP-1RA versus insulin therapy in real-world clinical practice [2]

They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer

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Gydesen S, Hjuler ST, Freving Z, Andreassen KV, Sonne N, Hellgren LI, Karsdal MA, Henriksen K

Tirzepatide commonly causes nausea, vomiting, diarrhea, and constipation, particularly during dose escalation