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The populations also differed: TRIUMPH-4 enrolled adults living with obesity and knee osteoarthritis over 68 weeks, while TRANSCEND-T2D-1 enrolled people living with type 2 diabetes over 40 weeks

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These findings open a new frontier in personalized neuroendocrine therapy, particularly relevant for postmenopausal women, who bear a disproportionate burden of AD and are often underrepresented in clinical trials