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An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 2526% and SBP 922% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]
Starting a GLP-1 taught me that struggling with weight is not a character flaw and obesity is not a choice
Given that altered expression and activity of DPP-4 are associated with increasing body mass index and hyperglycaemia, DPP-4 has been proposed to play a role in linking obesity and the pathogenesis of T2DM by functioning as a local mediator of inflammation and insulin resistance in adipose and hepatic tissue
DOI: Published online: February 14, 2024 1 Borthwick Diabetes Research Centre, Lister Hospital, Stevenage, UK 2 Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland Corresponding author: Adie Viljoen
