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It is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma (MTC) or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Circ Res 127(4):486501 Wang Y, Yan S, Liu X, Deng F, Wang P, Yang L, Hu L, Huang K, He J (2022) PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway

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It is not without interest that these potential additional indications, wherein determinations as to whether the evidence for GLP-1 RAs is definitive, also differentially affect SMI-SUD