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The mechanism is thought to involve direct melanocyte stimulation via MC1R, promoting melanocyte proliferation and migration into depigmented areas while UV-B provides the complementary stimulus for melanocyte activation

This effect may be attributed to the appetite-suppressing and weight-reducing effects of GLP-1 RAs, which decrease postprandial lipoprotein secretion and mitigate systemic inflammation

Neuron 108 , 11461162.e1110 (2020)

Further studies are needed to clarify the prognostic value of metabolic control in diabetic NETs patients and the effect of DPP-4i, SGLT2i, GLP-1RAs and the novel dual agonist tirzepatide on tumor outcomes

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