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This double-blind, placebo-controlled trial randomized (1:1) adults with body mass index 30 or 27 kg/m 2 and at least one obesity-related complication (excluding diabetes), who achieved 5.0% weight reduction after a 12-week intensive lifestyle intervention, to tirzepatide maximum tolerated dose (10 or 15 mg) or placebo once weekly for 72 weeks ( n = 579)