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Science 310 , 683685 (2005)

The relationship between weight gain, metabolism and hypothyroidism is complex and not well understood

Small molecules such as carbohydrates, amino acids, and hormones pass across the BBB using endothelial carrier-mediated transporters (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Banks, 2012)

Timing, Frequency, and Best Practices Optimal timing, frequency, and route of administration have not been definitively established