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Summary: Various tests measure B12 status, including plasma B12, homocysteine, MMA and holoTC

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Moreover, their effectiveness in the brain may be limited by their bioavailability, including an insufficient ability to cross the BBB and poor distribution in the brain regions, making it difficult for the antioxidant compound to reach target sites

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For many of these uses, high-quality human evidence and long-term safety data are limited or unavailable