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Activating both pathways simultaneously may provide metabolic benefits beyond those of GLP-1 activation alone supporting appetite control and blood sugar management at the same time

Topiramate's effect on weight reduction and long-term maintenance of body weight may be due to its effects on both appetite suppression and satiety enhancement, induced by a combination of pharmacologic effects including augmenting the activity of the neurotransmitter gamma-aminobutyrate, modulation of voltage-gated ion channels, inhibition of AMPA/kainite excitatory glutamate receptors, or inhibition of carbonic anhydrase

For the toxicity test, HCoEpiC cells were seeded into 96-well plates at a density of 1 10 cells per well and incubated overnight

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