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Although GLP-1RAs have inhibitory effect on sodium hydrogen exchanger-3 in tubules, it is unclear that renoprotective effect of GLP-1RAs is attributable to hemodynamic effect [44]

2.3 Gene-related effect 2.3.1 APOL1 gene variant High kidney disease risk of Africa has been linked to APOL1 high-risk alleles

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Satellite cell activation: Skeletal muscle has a population of stem-like satellite cells that, when activated, differentiate into myoblasts and fuse with existing muscle fibers literally adding new nuclei and increasing muscle fiber density