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Clinical Evidence: Muscle Preservation in Trials Phase 3 Lean Mass Data Retatrutide (23.9% weight loss): Lean mass loss: ~5.2% of body weight Lean mass as % of total loss: 21.8% Fat loss: 78.2% of total weight lost Tirzepatide (20.9% weight loss): Lean mass loss: ~6.8% of body weight Lean mass as % of total loss: 32.5% Fat loss: 67.5% of total weight lost Translation : At 220 lbs body weight with 26 lbs weight loss: Retatrutide achieves 2.5x better muscle preservation than semaglutide

Semaglutide is the active ingredient in Ozempic, which became famous for off-label weight loss

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

So, it can only be from exogenous sources

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