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IV glutathione has legitimate clinical evidence for hangover symptom reduction a 2022 study in the Journal of Clinical Biochemistry and Nutrition showed 42% symptom reduction with 1,200mg IV administration

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It also interacts with the brain to suppress appetite

Among these treatments, lifestyle changes should be the main focus for IR treatment, with nutritional intervention to decrease calories, avoidance of carbohydrates, and focusing on aliments with low glycemic index (including vegetables, fruits, whole-grain products, nuts, lean meats or beans) to provide higher fiber, vitamins, healthy fats and protein are particularly helpful for people trying to improve insulin sensitivity

Some evidence suggests that it may cause constipation when taken in high doses (27)