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( 10.2337/dc17-0417) [DOI] [PubMed] [Google Scholar] 105.Pratley RE, Aroda VR, Lingvay I, Ldemann J, Andreassen C, Navarria A, Viljoen A

Role of endogenous incretin hormones, GLP-1 and GIP, in cardiovascular physiology

Oral GLP-1 therapies emerged as game-changers: Rybelsus (oral semaglutide) was approved for diabetes in 2019, and in December 2025 the FDA approved Wegovys first oral pill (25 mg semaglutide) for obesity ( [35] )

But before you place your chips on the table, you need to understand the odds

GLP-1 receptor agonists are commonly associated with gastrointestinal adverse events, which may lead to dehydration in some people [112]