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OCR was recorded three times under basal conditions and three times after the addition of Mito Stress compounds (Mito Stress Test Kit, Agilent, Santa Clara, California, USA): oligomycin (oligo, 1 M, adenosine triphosphate (ATP)-synthase inhibitor), fluorocarbonyl cyanide phenylhydrazone (FCCP, 0.5 M, decoupler), and rotenone/antimycin A (rot/AA, 0.5 M, complex 3/1 inhibitor), as shown in Figure 1

When injected into the carotid artery of a transgenic mouse model of AD, curcumin was found to cross the blood-brain barrier, bind to amyloid plaques, and block the formation of A oligomers and fibrils (53)

10.1038/npp.2015.233 Neuropsychopharmacology 46 GaeckiP.TalarowskaM

doi: 10.1021/pr9009639

Basic hydration treatments are generally on the lower end of the cost spectrum, while more specialized therapies, such as those containing vitamins, antioxidants, and other beneficial compounds, may cost more