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"Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people"

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PMID 4180811

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

Over the years, it has been studied for obesity, metabolic disorders, and fat loss, and it is now used in wellness and performance clinics as a research peptide