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Emerging data implicates gut dysbiosisa disruption in microbial composition and functionin the pathogenesis of diverse diseases, including reproductive and gynecological disorders (118)

The high expression of CROT in male (statistically significant) and female (trend to increase) livers suggest that it is possible that ibuprofen treatment induces peroxisomal oxidation of medium and long chain fatty acids metabolism as a compensatory mechanism due to an overload of -oxidation of fatty acids in mitochondria

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In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ER , thereby improving cognitive function in Alzheimer's disease models