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Description

Lixisenatide and exenatide used in ELIXA and EXSCEL trials are short-acting GLP-1RAs that are structurally similar to exendin-4, a peptide found in the saliva of the Gila monster Heloderma suspectum

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10.1016/j.micron.2005.10.007 [DOI] [PubMed] [Google Scholar] Boini K

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5 The GLP-1 analogues are typically associated with weight loss of 2 to 4 kg in clinical trials and they reduce blood pressure by 2 to 4 mmHg, but they also increase heart rate by 2 to 4 beats/minute

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