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For most healthy adults, excess vitamin B12 from food or supplements is generally excreted in urine

More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes

(See Holford et al, 2013, for parameters in neonates and children.) Knowing the relationship between dose, drug concentration, and effects allows the clinician to take into account the various pathologic and physiologic features of a particular patient that make him or her different from the average individual in responding to a drug

doi: 10.1016/j.arr.2020.101131 174 ChenTJiaFYuYZhangWWangCZhuSet al

Interference in concentration