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Also, a small dropout rate and a high level of participants adherence (over 90%) were the other positive points

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He presented with an intra-oral brown macular lesion on the left buccal mucosa with a duration of one and a half months

But, the activity of the redox-sensitive citric acid cycle enzyme ACO2 in the brain has consistently been shown to decrease with aging (Sato et al., 2022), while DR was shown to increase mouse brain ACO2 persulfidation by 2-fold (Bithi et al., 2021), which may prevent ACO2 cysteine oxidation to preserve its activity