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FDA ADVISORY committee meeting

Her family history was negative for angioedema

By balancing glutamate and GABA, it directly targets the mechanisms driving mental fatigue and emotional dysregulation

The optimal dose identified in our murine model (200 mg/kgd, Supplementary Figure S2) corresponds to common clinical doses (adults: 13 g/d

At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off