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Trial registration European Union Drug Regulating Authorities Clinical Trials Database (EudraCT) 2019-000781-38 Graphical Abstract Similar content being viewed by others Introduction Chronic kidney disease (CKD) represents a serious and increasingly prevalent complication occurring in 3040% of individuals with type 2 diabetes [1]

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Protein aldehydes derived from LPO including 4-hydroxy-2-nonenal (4-HNE) which is formed during oxidative stress